antibacterial effect of the persian gulf sea cucumber holoturia. sp extracts on three strain of escherichia coli

objective: sea cucumber is a traditional food and medical item and has been reported to exhibit antioxidant, antifungal, anti tumoral and antibacterial bioactivity. the objective of this study is to describe the antibacterial activity of 4 extracts of holoturia. sp (sea cucumber), collected from hengam island of persian gulf. materials and methods: methanol, hexane, aqueous and chloroform extracts from body wall tissue of the sea cucumber were screened for antibacterial activity against three strains of escherichia coli top 10 f´, tg1 and k12 using disc diffusion and broth microdilution tests methods. result: the growth of all these strains were inhibited using concentration from 0.78 to 100 mg/ml of methanol, hexan and chloroform extracts. among the extracts just methanol and chloroform with 100 mg/ml had bactericidal effect on tg1 and k12 strains. on the other hand, aqueous extract had induced growth in of the all strains. conclusion: the results suggest the possibility of applying sea cucumber as source of potential anti bacterial agents, whose compounds can be good candidates to make antibiotic products.